Browse Hierarchy WHR7211: Application of Genomics in Infectious Disease

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The module will provide an introduction to the principles of microbial genome structure. It will cover microbial genome sequencing in support of diagnosis and guiding patient care as well as the impact of microbial diversity on understanding and preventing infectious diseases. The module will discuss the use of medical and biological and genetic information in tracking and managing infections and importantly antimicrobial resistance. The genomics of host-pathogen interactions will be discussed. The module will then cover the approaches for characterizing novel and emerging pathogens. Metagenomics as tools for deciphering complex microbial communities and how these influence the exchange of virulence mechanisms and microbial resistance genes within the host. Analysis of quasi-species through deep sequencing to demonstrate the impact of within host diversity on drug resistance and therapeutics particulalry for viral infections will be explained. Students will learn about the challenges that research is facing in determining host-parasite interactions and patient susceptibility.

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