Browse Hierarchy BIO325: Population and Chromosome Genetics

Pre-requisite: Transmission genetics OR Genes and Bioinformatics This module will introduce strategies and methods for identifying the molecular genetic basis of inherited human disorders and other traits in particular how linkage disequilibrium (LD) is used to identify the loci involved. It will use examples from the current literature to better understand genetic variation at a population and species level. It will examine quantitative traits in humans and other species; in particular the heritability estimates to infer the relative contribution of genes and the environment to important quantitative traits and disorders. Together the information will lead to an understanding of genetic drift and natural selection acting on the DNA sequence, the chromosome and genome organisation. The module will explore the evolution of genomic sequences and of chromosomes. Particular attention is paid to evolutionary processes observed at repetitive DNA sequences and the role of chromosomes in transmitting genetic material through mitosis and meiosis. It explores the role and evolution of sex chromosomes, the evolution of sex and of sexual selection. The course should students to achieve a critical understanding of thinking and research in the genetic processes of evolution.