1932

Abstract

Many major human neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), display axonal pathologies including abnormal accumulations of proteins and organelles. Such pathologies highlight damage to the axon as part of the pathogenic process and, in particular, damage to transport of cargoes through axons. Indeed, we now know that disruption of axonal transport is an early and perhaps causative event in many of these diseases. Here, we review the role of axonal transport in neurodegenerative disease.

Loading

Article metrics loading...

/content/journals/10.1146/annurev.neuro.31.061307.090711
2008-07-21
2024-03-28
Loading full text...

Full text loading...

/content/journals/10.1146/annurev.neuro.31.061307.090711
Loading
/content/journals/10.1146/annurev.neuro.31.061307.090711
Loading

Data & Media loading...

  • Article Type: Review Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error